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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P08559




USC-OGP 2-DE database:  P08559


P08559


General information about the entry
View entry in simple text format
Entry nameODPA_HUMAN
Primary accession numberP08559
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; EC=1.2.4.1; AltName: Full=PDHE1-A type I; Flags: Precursor;.
Gene nameName=PDHA1
Synonyms=PHE1A
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=6.07; Mw=43048

Cross-references
UniProtKB/Swiss-ProtP08559; ODPA_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameODPA_HUMAN
Primary accession numberP08559
Secondary accession number(s) A5YVE9 B2R5P7 B7Z3T7 B7Z3X5 Q53H41 Q5JPT8 Q9NP12 Q9UBJ8 Q9UBU0 Q9UNG4 Q9UNG5
Sequence was last modified on May 1, 1992 (version 3)
Annotations were last modified on March 15, 2017 (version 209)
Name and origin of the protein
DescriptionRecName: Full=Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; EC=1.2.4.1; AltName: Full=PDHE1-A type I; Flags: Precursor;
Gene nameName=PDHA1
Synonyms=PHE1A
Encoded onName=PDHA1; Synonyms=PHE1A
Keywords3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Glucose metabolism; Leigh syndrome; Mitochondrion; Oxidoreductase; Phosphoprotein; Polymorphism; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide; Tricarboxylic acid cycle.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD90084; BAA14121.1; -; Genomic_DNA
EMBLM24848; AAA36533.1; -; mRNA
EMBLX52709; CAA36933.1; -; mRNA
EMBLX52710; CAA36934.1; -; mRNA
EMBLM27257; AAA60051.1; -; Genomic_DNA
EMBLM29155; AAA60051.1; JOINED; Genomic_DNA
EMBLM29156; AAA60051.1; JOINED; Genomic_DNA
EMBLM29157; AAA60051.1; JOINED; Genomic_DNA
EMBLM29158; AAA60051.1; JOINED; Genomic_DNA
EMBLM29159; AAA60051.1; JOINED; Genomic_DNA
EMBLM29160; AAA60051.1; JOINED; Genomic_DNA
EMBLM29161; AAA60051.1; JOINED; Genomic_DNA
EMBLM29162; AAA60051.1; JOINED; Genomic_DNA
EMBLM29163; AAA60051.1; JOINED; Genomic_DNA
EMBLM29164; AAA60051.1; JOINED; Genomic_DNA
EMBLL13318; AAA60227.1; -; mRNA
EMBLJ03503; AAA60055.1; ALT_INIT; mRNA
EMBLJ03575; AAA60050.1; -; mRNA
EMBLL48690; AAB59581.1; ALT_FRAME; mRNA
EMBLEF590117; ABQ59099.1; -; mRNA
EMBLAK293250; BAH11476.1; -; mRNA
EMBLAK296457; BAH12361.1; -; mRNA
EMBLAK312263; BAG35194.1; -; mRNA
EMBLAK296341; BAH12323.1; -; mRNA
EMBLAK222740; BAD96460.1; -; mRNA
EMBLAL732326; CAI41291.1; -; Genomic_DNA
EMBLCH471074; EAW98960.1; -; Genomic_DNA
EMBLBC002406; AAH02406.1; -; mRNA
EMBLAF125053; AAD23841.1; -; Genomic_DNA
EMBLAF125054; AAD23842.1; -; Genomic_DNA
EMBLAF125055; AAD23843.1; -; Genomic_DNA
EMBLAF125056; AAD23844.1; -; Genomic_DNA
EMBLAF125057; AAD23845.1; -; Genomic_DNA
EMBLAF125058; AAD23846.1; -; Genomic_DNA
EMBLAF125059; AAD23847.1; -; Genomic_DNA
EMBLAF125060; AAD23848.1; -; Genomic_DNA
EMBLAF125061; AAD23849.1; -; Genomic_DNA
EMBLAF125062; AAD23850.1; -; Genomic_DNA
EMBLAF125063; AAD23851.1; -; Genomic_DNA
EMBLAF125064; AAD23852.1; -; Genomic_DNA
EMBLAF125065; AAD23853.1; -; Genomic_DNA
EMBLAF125066; AAD23854.1; -; Genomic_DNA
EMBLAF125067; AAD23855.1; -; Genomic_DNA
EMBLAF125068; AAD23856.1; -; Genomic_DNA
EMBLAF125069; AAD23857.1; -; Genomic_DNA
EMBLAF125070; AAD23858.1; -; Genomic_DNA
EMBLAF125071; AAD23859.1; -; Genomic_DNA
EMBLAF125072; AAD23860.1; -; Genomic_DNA
EMBLAF125073; AAD23861.1; -; Genomic_DNA
EMBLAF125074; AAD23862.1; -; Genomic_DNA
EMBLAF125075; AAD23863.1; -; Genomic_DNA
EMBLAF125076; AAD23864.1; -; Genomic_DNA
EMBLAF125078; AAD23866.1; -; Genomic_DNA
EMBLAF125079; AAD23867.1; -; Genomic_DNA
EMBLAF125080; AAD23868.1; -; Genomic_DNA
EMBLAF125081; AAD23869.1; -; Genomic_DNA
EMBLAF125082; AAD23870.1; -; Genomic_DNA
EMBLAF125083; AAD23871.1; -; Genomic_DNA
EMBLAF125084; AAD23872.1; -; Genomic_DNA
EMBLAF125085; AAD23873.1; -; Genomic_DNA
EMBLAF125086; AAD23874.1; -; Genomic_DNA
EMBLAF125087; AAD23875.1; -; Genomic_DNA
EMBLAF125088; AAD23876.1; -; Genomic_DNA
CCDSCCDS14192.1; -. [P08559-1]; .
CCDSCCDS55380.1; -. [P08559-4]; .
CCDSCCDS55381.1; -. [P08559-2]; .
CCDSCCDS55382.1; -. [P08559-3]; .
PIRJQ0770; DEHUPA; .
RefSeqNP_000275.1; NM_000284.3. [P08559-1]; .
RefSeqNP_001166925.1; NM_001173454.1. [P08559-4]; .
RefSeqNP_001166926.1; NM_001173455.1. [P08559-2]; .
RefSeqNP_001166927.1; NM_001173456.1. [P08559-3]; .
UniGeneHs.530331; -; .
PDB1NI4; X-ray; 1.95 A; A/C=30-390
PDB2OZL; X-ray; 1.90 A; A/C=30-390
PDB3EXE; X-ray; 1.98 A; A/C/E/G=30-390
PDB3EXF; X-ray; 3.00 A; A/C/E/G=30-390
PDB3EXG; X-ray; 3.01 A; 1/3/5/A/C/E/G/I/K/M/O/Q/S/U/W/Y=30-390
PDB3EXH; X-ray; 2.44 A; A/C/E/G=30-390
PDB3EXI; X-ray; 2.20 A; A=30-390
PDBsum1NI4; -; .
PDBsum2OZL; -; .
PDBsum3EXE; -; .
PDBsum3EXF; -; .
PDBsum3EXG; -; .
PDBsum3EXH; -; .
PDBsum3EXI; -; .
ProteinModelPortalP08559; -; .
SMRP08559; -; .
BioGrid111186; 52; .
DIPDIP-37652N; -; .
IntActP08559; 19; .
MINTMINT-3006251; -; .
DrugBankDB00157; NADH; .
iPTMnetP08559; -; .
PhosphoSitePlusP08559; -; .
SwissPalmP08559; -; .
BioMutaPDHA1; -; .
DMDM129063; -; .
REPRODUCTION-2DPAGEIPI00306301; -; .
UCD-2DPAGEP08559; -; .
EPDP08559; -; .
MaxQBP08559; -; .
PeptideAtlasP08559; -; .
PRIDEP08559; -; .
TopDownProteomicsP08559-3; -. [P08559-3]; .
TopDownProteomicsP08559-4; -. [P08559-4]; .
DNASU5160; -; .
EnsemblENST00000379806; ENSP00000369134; ENSG00000131828. [P08559-4]; .
EnsemblENST00000422285; ENSP00000394382; ENSG00000131828. [P08559-1]; .
EnsemblENST00000540249; ENSP00000440761; ENSG00000131828. [P08559-3]; .
EnsemblENST00000545074; ENSP00000438550; ENSG00000131828. [P08559-2]; .
GeneID5160; -; .
KEGGhsa:5160; -; .
UCSCuc004czg.5; human. [P08559-1]; .
CTD5160; -; .
DisGeNET5160; -; .
GeneCardsPDHA1; -; .
HGNCHGNC:8806; PDHA1; .
HPAHPA047487; -; .
HPAHPA047864; -; .
HPAHPA063053; -; .
MalaCardsPDHA1; -; .
MIM300502; gene; .
MIM312170; phenotype; .
neXtProtNX_P08559; -; .
OpenTargetsENSG00000131828; -; .
Orphanet70474; Leigh syndrome with cardiomyopathy; .
Orphanet79243; Pyruvate dehydrogenase E1-alpha deficiency; .
PharmGKBPA33150; -; .
GeneTreeENSGT00530000063174; -; .
HOGENOMHOG000281336; -; .
HOVERGENHBG001863; -; .
InParanoidP08559; -; .
KOK00161; -; .
OMAWMYQKML; -; .
OrthoDBEOG091G0966; -; .
PhylomeDBP08559; -; .
TreeFamTF300742; -; .
BioCycMetaCyc:HS05573-MONOMER; -; .
BRENDA1.2.4.1; 2681; .
ReactomeR-HSA-204174; Regulation of pyruvate dehydrogenase (PDH) complex; .
ReactomeR-HSA-389661; Glyoxylate metabolism and glycine degradation; .
ReactomeR-HSA-5362517; Signaling by Retinoic Acid; .
ReactomeR-HSA-70268; Pyruvate metabolism; .
SABIO-RKP08559; -; .
SIGNORP08559; -; .
ChiTaRSPDHA1; human; .
EvolutionaryTraceP08559; -; .
GeneWikiPyruvate_dehydrogenase_(lipoamide)_alpha_1; -; .
GenomeRNAi5160; -; .
PROPR:P08559; -; .
ProteomesUP000005640; Chromosome X; .
BgeeENSG00000131828; -; .
CleanExHS_PDHA1; -; .
ExpressionAtlasP08559; baseline and differential; .
GenevisibleP08559; HS; .
GOGO:0005759; C:mitochondrial matrix; TAS:Reactome; .
GOGO:0005739; C:mitochondrion; IDA:UniProtKB; .
GOGO:0043209; C:myelin sheath; IEA:Ensembl; .
GOGO:0005730; C:nucleolus; IDA:HPA; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0045254; C:pyruvate dehydrogenase complex; IDA:UniProtKB; .
GOGO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC; .
GOGO:0034604; F:pyruvate dehydrogenase (NAD+) activity; IEA:Ensembl; .
GOGO:0004738; F:pyruvate dehydrogenase activity; IDA:UniProtKB; .
GOGO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:UniProtKB; .
GOGO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW; .
GOGO:0046487; P:glyoxylate metabolic process; TAS:Reactome; .
GOGO:0061732; P:mitochondrial acetyl-CoA biosynthetic process from pyruvate; IEA:Ensembl; .
GOGO:0006090; P:pyruvate metabolic process; TAS:Reactome; .
GOGO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome; .
GOGO:0006099; P:tricarboxylic acid cycle; IDA:UniProtKB; .
Gene3D3.40.50.970; -; 1; .
InterProIPR001017; DH_E1; .
InterProIPR017597; Pyrv_DH_E1_asu_subgrp-y; .
InterProIPR029061; THDP-binding; .
PfamPF00676; E1_dh; 1; .
SUPFAMSSF52518; SSF52518; 1; .
TIGRFAMsTIGR03182; PDH_E1_alph_y; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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